Alliance Digital Pathology Image Portal (DPI)

Summary: The submission of diagnostic, stained pathology tissue slides is an important aspect of many Alliance trials, both for central pathology review and more recently, AI-based imaging correlative studies. We understand that institutions are frequently reluctant to release diagnostic pathology slides for review and are making increasing use of digitized pathology images (aka “whole slide images (WSI)” or “scanned slide images”), which can be transmitted and reviewed in lieu of actual glass slides. In order to facilitate the submission of diagnostic pathology images and decrease the work burden to our clinical sites, on Feb 1, 2024, the Alliance BioMS specimen submission system went live with its Digital Pathology Image (DPI) Portal. The DPI portal is integrated into the BioMS application and allows sites to submit scanned slide images as an alternate to most stained, glass slide requirements in Alliance trials.

The following are the steps to be followed to securely upload a set of digital images (up to 15 files) for a Patient enrolled in an Alliance Oncology Clinical Trial accepting digital pathology images. Before doing the specimen upload, please read the instructions listed at the top of the Log Specimens page.

STEP-0 Read instructions for logging specimens

STEP-1: Please pull up the Patient check list in BioMS using the Patient ID for which the protocol defines and accepts digital pathology images. For these specimens, an icon, as highlighted below, will be shown next to the Specimen Actions. In the example shown below, the Digital Pathology Image is shown as an alternate and as you can see, the Primary specimen, FFPE Tumor Block, is updated as “Not Collected” as a first step.

STEP-2: Click on the digital pathology specimen Upload icon. Alliance Digital Pathology Image Portal will open on a new Browser tab. Please verify the Study ID, Patient ID and Collection Arm and Collection Event which are displayed at the top.