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Summary: Alliance clinical trials have an increasing requisite for the collection of a large number of biofluids. Currently, aliquots of biofluid samples are stored in conventional -80 freezers or (in the case of ABWUSTL) liquid nitrogen vapor. Current procedures require that clinical sites provide their own vials for biofluid sample aliquoting and storage (which are often in multiple and inappropriate sizes and formats for biobanking) and label these tubes by hand with multiple pieces of information to maintain a robust ‘chain of identity.’  This is difficult, time consuming, and resource straining for many clinical sites. If biosample tubes are labeled at the site, the biobank must remove / redact such labels and replace them with unique biobank identifiers before storage to maintain a de-identified chain of identity.  This is burdensome and time consuming for biobanks and susceptible to sample misidentification. To address these limitations, effective from March 1, 2025, the Alliance Biorepository at Washington University (ABWUSTL) plans to leverage a new facility at Washington University School of Medicine for the automated storage and retrieval of biofluid sample aliquots. The CTBI BioStore is essentially a Hamilton BiOS robotic, high-density freezer unit.

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