Summary: Alliance clinical trials have an increasing requisite for the collection of a large number of biofluids. Currently, aliquots of biofluid samples are stored in conventional -80 freezers or (in the case of ABWUSTL) liquid nitrogen vapor. Current procedures require that clinical sites provide their own vials for biofluid sample aliquoting and storage (which are often in multiple and inappropriate sizes and formats for biobanking) and label these tubes by hand with multiple pieces of information to maintain a robust ‘chain of identity.’ This is difficult, time consuming, and resource straining for many clinical sites. If biosample tubes are labeled at the site, the biobank must remove / redact such labels and replace them with unique biobank identifiers before storage to maintain a de-identified chain of identity. This is burdensome and time consuming for biobanks and susceptible to sample misidentification. To address these limitations, the Alliance Biorepository at Washington University (ABWUSTL) plans to leverage a new facility at Washington University School of Medicine, the Center for Translational Bioinformatics (CTBI) BioStore, for the automated storage and retrieval of biofluid sample aliquots. The CTBI BioStore is essentially a Hamilton BioS robotic, high-density freezer unit.
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Step:1 Login to BioMS and go to the Patient Checklist page for the Patient. The patient id shown here is a ficitous patient and the study is a Test Study. |
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Step-2 Enter the collection date for the fluid specimen; plasma. You can do this by simply clicking the checkbox against it. System will put the collection date and time as current date and time which can be changed, if needed. Also, if the collected quantity is less than the default Quantity shown, then change the quantity to the correct total quantity value at this step. In the example shown here, only 2 tubes totalling 4ml is collected. Therefore, the quantity is changed to 4ml from the default value of 6ml. |
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Step: 6 Select the checkbox against the specimen and then click the green arrow to put the specimen into a Shipment. Select the created shipment and then click send. Please note that the BioMS Shipment Manifest shows the barcodes of the tubes against the specimen in the Specimen Table. Also, the same information is displayed under specimen comments. In addtion, there is a note ” Pre-labeled barcoded barcoded tubes are included in this shipment” that appears on the BioMS Shipment Manifest as an alert to the Repository staff. |
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